Retinal layer analysis uses OCT segmentation to measure the thickness and integrity of individual retinal layers across the macula or peripapillary region. It provides detailed structural information beyond overall thickness.
Technique
Software algorithms delineate boundaries between layers such as nerve fibre, ganglion cell, inner nuclear, and outer segments. Thickness and volume maps are generated and compared with normative data.
- Requires high-quality scans and accurate automated or manual segmentation
- Layer-specific abnormalities can be localised to particular diseases
- Data may be exported for research or longitudinal analysis
- Can be applied to both macular and disc-centred scans
Clinical Uses
Layer analysis assists in understanding and monitoring conditions like glaucoma, optic neuritis, macular dystrophies, and retinal vascular disease. It links structural loss in specific layers with functional deficits.
- Helps differentiate outer retinal from inner retinal pathology
- Supports research into neurodegenerative and systemic diseases affecting the retina
- Progression analysis focuses on layers most relevant to the condition
- Interpretation must account for segmentation errors and anatomical variation
