Isotretinoin is a strong reason to delay laser eye surgery, because it can cause marked dry eye and impair corneal healing.
Why isotretinoin is a concern
This acne medication affects oil glands throughout the body, including those in the eyelids.
- Reduced meibomian gland secretion and unstable tear film
- Higher risk of severe postoperative dryness and discomfort
- Potential for delayed epithelial healing after surface procedures
- Increased chance of scarring or haze with PRK‑type treatments
- Most guidelines recommend avoiding laser during treatment and for a period afterwards
Timing surgery safely
A washout interval allows the tear film and ocular surface to recover.
- Typical recommendation of several months off isotretinoin before assessment
- Ocular surface evaluation with staining and tear tests prior to planning
- Lid hygiene and lubricants to restore comfort before surgery
- Refractive consultation once skin and eye side‑effects have settled
- Alternative, non‑surgical vision correction in the meantime
