Werner syndrome is a rare autosomal recessive disorder causing features of premature ageing from early adulthood. Eye problems are part of a broader multisystem picture.
Ocular and systemic signs
The condition usually presents with short stature and early greying of hair.
- Early-onset bilateral cataracts are very common
- Skin atrophy, ulcers, and characteristic facial appearance
- Increased risk of diabetes, atherosclerosis, and malignancies
- WRN gene mutations affecting DNA repair
Management
Treatment is supportive and complication-focused.
- Timely cataract surgery to restore vision
- Monitoring and management of cardiovascular and metabolic risk
- Regular cancer surveillance where recommended
- Genetic counselling for affected families
