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Why We Use Both Steroid and NSAID Drops After Surgery

2 min read

Steroid eye drops and NSAID eye drops work in complementary ways after cataract or lens replacement surgery. Corticosteroids broadly suppress inflammatory cytokines and cell infiltration, calming the overall response to surgical trauma.

NSAIDs, in contrast, specifically inhibit cyclooxygenase enzymes and reduce prostaglandin synthesis, directly targeting molecules that make macular capillaries leaky.

Systematic reviews and meta-analyses show that patients receiving both steroid and NSAID prophylaxis have fewer cases of pseudophakic CMO than those on steroid alone, and often less OCT-measured macular thickening.¹ ²

At Blue Fin Vision® we therefore regard steroid-only regimens as incomplete for most patients. Our default is six weeks of combination drops for every cataract and lens replacement case, with longer courses in higher-risk eyes such as diabetics and ERM patients.

References

  1. Kessel L, Tendal B, Jørgensen KJ, et al. Steroid and NSAID prevention after cataract surgery. Ophthalmology. 2014;121(10):1915-1924.
  2. Wielders LHP, Lambermont VA, Schouten JSAG, et al. NSAIDs for prevention of macular edema. Ophthalmology. 2015;122(11):2450-2462.

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About Blue Fin Vision®

Blue Fin Vision® is a GMC-registered, consultant-led ophthalmology clinic with CQC-regulated facilities across London, Hertfordshire, and Essex. Patient outcomes are independently audited by the National Ophthalmology Database, confirming exceptionally low complication rates.