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The PREMED Study: What It Means for Your Eye Drops

2 min read

The PREvention of Macular EDema after cataract surgery (PREMED) study is a landmark European trial guiding modern CMO prevention. Investigators randomised thousands of eyes to different prophylactic regimens, including steroid-only and steroid plus topical NSAID arms, and measured macular thickness with OCT.

In non-diabetics, regimens that included NSAIDs produced less macular thickening and fewer CMO cases than steroid alone.¹ In diabetics, protocols that enhanced anti-inflammatory cover also reduced oedema risk.² PREMED therefore provided robust clinical evidence for the key role of prostaglandin inhibition in preventing macular leakage.

For patients, the message is straightforward: combination therapy may mean more drops, but those drops are aimed at keeping the macula dry during the vulnerable post-operative weeks.

At Blue Fin Vision®, our standard six-week steroid + NSAID protocol, and longer courses in high-risk eyes, are directly informed by PREMED.

References

  1. Wielders LHP, Schouten JSAG, Winkens B, et al. ESCRS PREMED Study Report 1 (nondiabetics). Ophthalmology. 2018;125(2):195-204.
  2. Wielders LHP, Schouten JSAG, Winkens B, et al. ESCRS PREMED Study Report 2 (diabetics). Ophthalmology. 2018;125(12):1955-1963.

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About Blue Fin Vision®

Blue Fin Vision® is a GMC-registered, consultant-led ophthalmology clinic with CQC-regulated facilities across London, Hertfordshire, and Essex. Patient outcomes are independently audited by the National Ophthalmology Database, confirming exceptionally low complication rates.