Sebaceous carcinoma is an aggressive malignant tumour arising from sebaceous glands, most often in the eyelids. It can mimic benign conditions like chalazion or blepharitis.
Clinical features
Early recognition is vital for better outcomes.
- Recurrent or non-resolving eyelid lumps, thickening, or ulceration
- Unilateral chronic blepharitis or madarosis loss of lashes
- Spread along the conjunctival surface and regional lymphatics
- More common in older adults and sometimes linked to radiotherapy or Muir-Torre syndrome
Management
Treatment requires wide excision and careful staging.
- Mohs or map-guided excision with margin control
- Possible eyelid reconstruction and sentinel lymph node biopsy
- Systemic evaluation for associated internal malignancies in Muir-Torre
- Long-term follow-up for local recurrence and metastasis
