AlphaCor is a type of synthetic keratoprosthesis made entirely from hydrogel material designed to integrate with the host cornea. It has been used in selected cases of bilateral corneal blindness unsuitable for standard grafting.
Structure and Implantation
The device has a central transparent optic and a peripheral skirt with porous structure to allow tissue ingrowth. Implantation is typically staged, with initial placement in a corneal pocket followed later by exposure of the optic.
- Aims to reduce issues related to donor tissue dependence
- Indications include non‑inflammatory corneal opacities with relatively healthy ocular surface
- Less commonly used in recent years compared with Boston KPro
- Requires careful surgical technique and long‑term follow‑up
Complications and Outcomes
Complications reported include melting, extrusion, infection, and glaucoma. Visual results can be good in successful cases but device survival may be limited.
- Regular monitoring of interface integrity and intraocular pressure is essential
- Prophylactic medications and protective lenses may be required
- Alternative keratoprosthesis types or low‑vision strategies might be preferable depending on case
- Discussion with a corneal specialist familiar with current evidence is important
