Peters anomaly is a congenital disorder in which the central cornea is cloudy and adherent to abnormal iris or lens structures, reflecting a more severe form of anterior segment dysgenesis. It often presents in infancy with reduced visual clarity.
Features
The condition is characterised by a central corneal opacity, defects in the posterior cornea, and adhesions between the iris or lens and the corneal defect. It may affect one or both eyes and is associated with a high risk of amblyopia and glaucoma.
- Corneal opacity can range from mild to dense
- Anterior chamber is often shallow with abnormal angle structures
- Lens changes or cataract may be present
- Systemic or craniofacial anomalies occur in some syndromic forms
Management
Management is complex and may include medical and surgical treatment of glaucoma, corneal transplantation, and lens surgery, alongside intensive amblyopia therapy. Early referral to specialist paediatric ophthalmology services is important.
- Long-term follow-up is required to monitor visual development
- Prognosis varies widely depending on severity and associated anomalies
- Genetic evaluation may identify underlying syndromes
- Support for families helps with decision-making about surgical options
