---
title: Werner syndrome
description: "Werner syndrome is a rare autosomal recessive disorder causing features of premature ageing from early adulthood. Eye problems are part of a broader multisystem picture. ## Ocular and systemic signs The condition usually presents with short stature and early greying…"
url: "https://bluefinvision.com/knowledge-base/topics/conditions-diseases/werner-syndrome/"
updated: "2025-12-16"
category: "Conditions & Diseases"
---

# Werner syndrome

Werner syndrome is a rare autosomal recessive disorder causing features of premature ageing from early adulthood. Eye problems are part of a broader multisystem picture.

## Ocular and systemic signs

The condition usually presents with short stature and early greying of hair.

- Early-onset bilateral cataracts are very common
- Skin atrophy, ulcers, and characteristic facial appearance
- Increased risk of diabetes, atherosclerosis, and malignancies
- WRN gene mutations affecting DNA repair

## Management

Treatment is supportive and complication-focused.

- Timely cataract surgery to restore vision
- Monitoring and management of cardiovascular and metabolic risk
- Regular cancer surveillance where recommended
- Genetic counselling for affected families