---
title: Sjögren’s syndrome
description: "Sjögren's syndrome is an autoimmune disease that targets moisture-producing glands, leading to dry eyes and dry mouth. It may occur alone or with other autoimmune conditions. ## Ocular manifestations Dry eye is often the earliest or most troublesome symptom. -…"
url: "https://bluefinvision.com/knowledge-base/topics/conditions-diseases/sjogrens-syndrome/"
updated: "2025-12-16"
category: "Conditions & Diseases"
---

# Sjögren’s syndrome

Sjögren's syndrome is an autoimmune disease that targets moisture-producing glands, leading to dry eyes and dry mouth. It may occur alone or with other autoimmune conditions.

## Ocular manifestations

Dry eye is often the earliest or most troublesome symptom.

- Burning, grittiness, redness, and fluctuating blurred vision
- Stringy mucus and difficulty wearing contact lenses
- Potential for filamentary keratitis and corneal ulcers in severe cases
- Associated positive autoantibodies such as anti-Ro/SSA

## Management

Treatment aims to relieve dryness and prevent surface damage.

- Frequent preservative-free lubricants and gels
- Punctal plugs, topical cyclosporine, or lifitegrast for moderate-severe disease
- Systemic evaluation and immunomodulatory therapy when indicated
- Regular monitoring for lymphoma risk in long-standing disease