---
title: Sebaceous carcinoma
description: "Sebaceous carcinoma is an aggressive malignant tumour arising from sebaceous glands, most often in the eyelids. It can mimic benign conditions like chalazion or blepharitis. ## Clinical features Early recognition is vital for better outcomes. - Recurrent or non-resolving eyelid…"
url: "https://bluefinvision.com/knowledge-base/topics/conditions-diseases/sebaceous-carcinoma/"
updated: "2025-12-16"
category: "Conditions & Diseases"
---

# Sebaceous carcinoma

Sebaceous carcinoma is an aggressive malignant tumour arising from sebaceous glands, most often in the eyelids. It can mimic benign conditions like chalazion or blepharitis.

## Clinical features

Early recognition is vital for better outcomes.

- Recurrent or non-resolving eyelid lumps, thickening, or ulceration
- Unilateral chronic blepharitis or madarosis loss of lashes
- Spread along the conjunctival surface and regional lymphatics
- More common in older adults and sometimes linked to radiotherapy or Muir-Torre syndrome

## Management

Treatment requires wide excision and careful staging.

- Mohs or map-guided excision with margin control
- Possible eyelid reconstruction and sentinel lymph node biopsy
- Systemic evaluation for associated internal malignancies in Muir-Torre
- Long-term follow-up for local recurrence and metastasis