---
title: Presumed ocular histoplasmosis syndrome (POHS)
description: "Presumed ocular histoplasmosis syndrome POHS is a retinal condition linked to previous infection with the fungus Histoplasma capsulatum. It can cause sight-threatening choroidal neovascularisation near the macula. ## Features and symptoms Most people with POHS have no active infection, only…"
url: "https://bluefinvision.com/knowledge-base/topics/conditions-diseases/presumed-ocular-histoplasmosis-syndrome-pohs/"
updated: "2025-12-16"
category: "Conditions & Diseases"
---

# Presumed ocular histoplasmosis syndrome (POHS)

Presumed ocular histoplasmosis syndrome POHS is a retinal condition linked to previous infection with the fungus Histoplasma capsulatum. It can cause sight-threatening choroidal neovascularisation near the macula.

## Features and symptoms

Most people with POHS have no active infection, only old scars. Vision changes occur if new vessels form.

- Punched-out atrophic scars in the mid-periphery and around the optic disc
- Absence of significant vitreous inflammation
- Distortion or central blur when choroidal neovascular membranes develop
- More common in people from histoplasmosis-endemic regions

## Treatment

Management focuses on treating any choroidal neovascularisation and monitoring the fellow eye.

- Intravitreal anti-VEGF injections for active neovascular membranes
- OCT and angiography to guide treatment and follow-up
- Self-monitoring with an Amsler grid to detect new distortion
- Low-vision support if central scarring is advanced