---
title: "Melkersson-rosenthal syndrome (MRS)"
description: "Melkersson-Rosenthal syndrome is a rare condition characterised by recurrent facial swelling, facial nerve palsy, and a fissured tongue. Eyelid and orbital tissues may be involved. ## Ocular and facial features The classic triad may not be present in every patient.…"
url: "https://bluefinvision.com/knowledge-base/topics/conditions-diseases/melkersson-rosenthal-syndrome-mrs/"
updated: "2025-12-16"
category: "Conditions & Diseases"
---

# Melkersson-rosenthal syndrome (MRS)

Melkersson-Rosenthal syndrome is a rare condition characterised by recurrent facial swelling, facial nerve palsy, and a fissured tongue. Eyelid and orbital tissues may be involved.

## Ocular and facial features

The classic triad may not be present in every patient.

- Recurrent painless swelling of the lips or eyelids
- Episodes of facial nerve weakness causing lagophthalmos
- Furrowed or fissured tongue glossitis
- Granulomatous inflammation on biopsy

## Management

Treatment is often symptomatic and tailored.

- Corticosteroids or other immunomodulators for acute flares
- Lid surgery or gold weights if exposure threatens the cornea
- Speech and dietary advice for tongue involvement
- Multidisciplinary care with neurology and dermatology