---
title: Dense deposit disease
description: "Dense deposit disease is a complement-mediated kidney disorder now grouped under C3 glomerulopathies. It can also affect the eye through drusen-like deposits. ## Ocular manifestations Abnormal complement activation leads to deposits in Bruch's membrane and choroid. - Development of macular…"
url: "https://bluefinvision.com/knowledge-base/topics/conditions-diseases/dense-deposit-disease/"
updated: "2025-12-16"
category: "Conditions & Diseases"
---

# Dense deposit disease

Dense deposit disease is a complement-mediated kidney disorder now grouped under C3 glomerulopathies. It can also affect the eye through drusen-like deposits.

## Ocular manifestations

Abnormal complement activation leads to deposits in Bruch's membrane and choroid.

- Development of macular drusen in children or young adults
- Risk of choroidal neovascularisation and visual loss
- Fundus changes resembling early age-related macular degeneration but at younger ages
- Need for regular retinal assessments in affected patients

## Management

Treatment focuses on renal disease and monitoring ocular complications.

- Nephrology-led complement-targeted or supportive therapy
- Anti-VEGF injections for any choroidal neovascularisation
- Control of blood pressure and other vascular risk factors
- Low-vision support if macular scarring develops